This just happened to me, which is why I researched it and found this article. Opening an Excel spreadsheet (same spreadsheet I use every year with my Xmas card list) and it triggered. It didn't keep me from opening the spreadsheet, just gave me a Defender alert and when I checked the log, it said it killed two processes running Win32/PowEmotet.SB
https://www.bleepingcomputer.com/news/m ... positives/
Microsoft Defender scares admins with Emotet false positives
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Microsoft Defender scares admins with Emotet false positives
"Turns out I’m 'woke.' All along, I thought I was just compassionate, kind, and good at history. "