Update: For some reason, I got a bug up my butt to check for a BIOS update. Since I was 4 versions behind I decided to update. The update mostly went off without a hitch. If you use MSI's Dragon Center software, it will download the BIOS, restart, and then not update. The BIOS on these boards must be flashed from a USB stick. After doing so, I rebooted and didn't have any problems playing the Sims 3 for a couple hours followed by Dark Souls 3 for about an hour and a half. Then I plugged in my Blu-Ray drive, started PowerDVD, and got a Blue Screen 5 minutes into watching. I ran BlueScreenView and found the following:
I checked for and updated the Chipset Drivers and Sound Drivers. I Ran Intel's Stress test on the memory and CPU and Intel's Diagnostic Tool. Everything Passed. I then continued to watch by BluRay for an additional 2 hours without issue. I decided to check the BIOS and I think I found the issue. The XMP profile got turned off by the Update. The memory was running at default 2133 instead of 3200. This shouldn't bee an issue but it was also under voltage. This RAM should be 1.36 and was running at 1.25. I turned the profile back on and everything seems to be running smoothly. I did have PowerDVD crap out on me but it was an error communicating with the player. I used to get those on my old system from time to time and think it has more to do with PowerDVD (I hope).
tl;dr
Updating the BIOS on MSI's newer boards resets your memory settings. PowerDVD is still flaky after 15 versions. The two combined may cause a BSOD.